Delaware State Route 52 is a north-south highway in Northern Delaware. It runs from BUSN U.S. Rt. 13 in Wilmington, to the Pennsylvania/Delaware State Line, near Wynleigh. DE St Rt 52 passes through the following towns in New Castle County. Wilmington Greenville Wynleigh DE St Rt 52 is not multi-plexed in New Castle County. DE St Rt 52 intersects the following highways in New Castle County. BUSN U.S. Rt. 13, at Wilmington. Interstate 95, at Wilmington. U.S. Rt. 202, at Wilmington. Delaware State Route 2, in Wilmington. Delaware State Route 100, at Greenville. Delaware State Route 141, at Greenville. Delaware State Route 82, at Greenville.