Illinois State Route 100 is a north-south highway in Jersey County. It runs along the Mississippi and Illinois Rivers in the county. This access many state park accesses. IL St Rt 100 passes through the following towns in Jersey County. Grafton
Nutwood IL St Rt 100 is multi-plexed in Jersey County. Illinois State Route 16, from near Nutwood to the Jersey/Greene County Line.
IL St Rt 100 intersects the following highways in Jersey County. Illinois State Route 3, at Grafton.
SB IL St Rt 100 south of Grafton. A Jersey County mile marker. NB IL St Rt 100 near Rosedale. WB IL St Rt 16/NB IL St Rt 100 near the Greene/Jersey County Line. EB IL St Rt 16/SB IL St Rt 100 at the Greene/Jersey County Line.