Illinois State Route 116 runs east-west across the northern portion of Fulton County. It enters from Knox County, near London Mills, and runs east to Peoria County, at Farmington. The entire time is runs just south of the Fulton/Knox County Line. IL St Rt 116 passes through the following towns in Fulton County. London Mills
EB IL St Rt 116 at the Fulton/Knox County Line. EB IL St Rt 116 east of London Mills. EB IL St Rt 116 west of Middlegrove. EB IL St Rt 116 east of Middlegrove. NB IL St Rt 78/EB IL St Rt 116 in Downtown Farmington. NB IL St Rt 78/EB IL St Rt 116 in Farmington. SB IL St Rt 78/EB IL St Rt 116 at the Fulton/Peoria County Line.