Illinois State Route 16 runs east-west across the southwestern tip of Christian County. This is the main route through the town of Pana. IL St Rt 16 passes through the following towns in Christian County. Pana
IL St Rt 16 is multi-plexed in Christian Cunty. U.S. Rt. 51, at Pana.
IL St Rt 16 intersect the following highways in Christian County. U.S. Rt. 51, east of Pana.