Illinois State Route 16 is one of two highways that run east-west across Macoupin County. This is the southern most of the two. IL St Rt 16 passes through the following towns in Macoupin County. East Gillespie
Gillespie
Shipman
Piasa
IL St Rt 16 is multi-plexed in Macoupin County. Illinois State Route 4, at Gillespie. IL St Rt 16 intersects the following highways in Macoupin County. Illinois State Route 4, at Gillespie.
EB IL St Rt 16 east of East Gillespie. EB IL St Rt 16 east of north IL St Rt 4. A junction marker on SB IL St Rt 4/WB IL St Rt 16. A Macoupin County mile marker. EB IL St Rt 16, east of Royal Lakes. EB IL St Rt 16 east of IL St Rt 159. WB IL St Rt 16, west of Royal Lake. WB IL St Rt 16 in Piasa.
