Illinois State Route 16 is one of two highways that run east-west across Macoupin County. This is the southern most of the two. IL St Rt 16 passes through the following towns in Macoupin County. East Gillespie
Gillespie
Shipman
Piasa
IL St Rt 16 is multi-plexed in Macoupin County. Illinois State Route 4, at Gillespie. IL St Rt 16 intersects the following highways in Macoupin County. Illinois State Route 4, at Gillespie.
