Illinois State Route 17 runs briefly through the northeast corner of Knox County. IL St Rt 17 does not pass through any towns in Knox County. IL St Rt 17 is not multi-plexed in Knox County. IL St Rt 17 intersects the following highway in Knox County. Illinois State Route 180, near La Fayette.
WB IL St Rt 17 east of IL St Rt 180. EB IL St Rt 17 at the Henry/Knox County Line.