Illinois State Route 53 runs north-south through much of the northwestern tip of Cook County. This highway runs along a expressway from the Lake/Cook County Line to near the Du Page/Cook County Line. IL St Rt 53 passes through the following towns in Cook County. Elk Grove Village
Schaumburg
Rolling Meadows
Alrington Heights
Palatine IL St Rt 53 is multi-plexed in Cook County. Interstate 290, from Elk Grove Village to Schaumburg.
SB IL St Rt 53 at Nerge Road. A BGS on WB I-290. A BGS on WB I-290. A BGS on WB I-290. A BGS on WB I-290. A BGS on WB I-290. A BGS on EB I-290/SB IL St Rt 53. A BGS on EB I-290/SB IL St Rt 53. A BGS on EB I-290/SB IL St Rt 53. WB I-290/NB IL St Rt 53 near I-90. WB I-290/NB IL St Rt 53 over 2 miles from I-90. (2015) WB I-290/NB IL St Rt 53 over 2 miles from I-90. (September, 2019) WB I-290/NB IL St Rt 53 one mile from I-90. (2015) WB I-290/NB IL St Rt 53 one mile from I-90. (September, 2019) BGS's on NB IL St Rt 53 in Schaumburg. WB I-290/NB IL St Rt 53 at the start of the C/D lanes at the I-90 interchange. A junction marker in Schaumburg. A guide marker in Schaumburg. A guide marker on Golf Road. A BGS on EB I-90. A BGS on WB I-90. A BGS on EB I-90. A BGS on EB I-90. A BGS on WB I-90. A BGS on WB I-90. SB IL St Rt 53 north of I-90/290. A guide marker on IL St Rt 62. SB IL St Rt 53 north of IL St Rt 62. NB IL St Rt 53 in Rolling Meadows. A junction marker on WB U.S. Rt. 14. A guide sign on WB U.S. Rt. 14. A guide marker on WB U.S. Rt. 14. NB IL St Rt 53 near IL St Rt 68. A BGS on NB IL St Rt 53 at IL St Rt 68. A junction marker on WB IL St Rt 68. A BGS on WB IL St Rt 68 for SB IL St Rt 53. A BGS on Lake-Cook Road. EB U.S. Rt. 12/SB IL St Rt 53 in Palatine.
