Illinois State Route 78 runs in the Southeastern Knox County. It runs from from near Yates City to north of Farmington. IL St Rt 78 does not pass through any towns in Knox County. IL St Rt 78 is multi-plexed in Knox County. Illinois State Route 8, near Yates City.
IL St Rt 78 intersects the following highway in Knox County. Illinois State Route 8, near Yates City.
