U.S. Federal Route 45 runs north-south through Douglas County. This is near the center of the county. It runs along the west side of Interstate 57, connecting the towns that I-57 bypasses. U.S. Rt. 45 passes through the following towns in Douglas County. Tuscola Galton Arcola
U.S. Rt. 45 is not multi-plexed in Douglas County. U.S. Rt. 45 intersects the following highways in Douglas County. U.S. Rt. 36, at Tuscola.