U.S. Federal Route 45 runs north-south through Douglas County. This is near the center of the county. It runs along the west side of Interstate 57, connecting the towns that I-57 bypasses. U.S. Rt. 45 passes through the following towns in Douglas County. Tuscola Galton Arcola
U.S. Rt. 45 is not multi-plexed in Douglas County. U.S. Rt. 45 intersects the following highways in Douglas County. U.S. Rt. 36, at Tuscola.
SB U.S. Rt. 45 at the Champaign/Douglas County Line. A junction marker on WB U.S. Rt. 36. SB U.S. Rt. 45 at Arcola. NB U.S. Rt. 45 at Arcola. SB U.S. Rt. 45 south of Arcola. NB U.S. Rt. 45 at the Coles/Douglas County Line.
