U.S. Federal Route 45 runs north-south through Douglas County. This is near the center of the county. It runs along the west side of Interstate 57, connecting the towns that I-57 bypasses. U.S. Rt. 45 passes through the following towns in Douglas County. Tuscola Galton Arcola
U.S. Rt. 45 is not multi-plexed in Douglas County. U.S. Rt. 45 intersects the following highways in Douglas County. U.S. Rt. 36, at Tuscola.
SB U.S. Rt. 45 at the Champaign/Douglas County Line. SB U.S. Rt. 45 north of Tuscola. SB U.S. Rt. 45 north of U.S. Rt. 36. SB U.S. Rt. 45 at WB U.S. Rt. 36. SB U.S. Rt. 45 going over U.S. Rt. 36. A junction marker on WB U.S. Rt. 36. SB U.S. Rt. 45 south of U.S. Rt. 36. SB U.S. Rt. 45 north of Arcola. SB U.S. Rt. 45 at Arcola. NB U.S. Rt. 45 at Arcola. SB U.S. Rt. 45 south of Arcola. SB U.S. Rt. 45 south of IL St Rt 133. NB U.S. Rt. 45 at the Coles/Douglas County Line.
