U.S. Federal Route 45 runs north-south through the center portion of Lake county. U.S. Rt. 45 passes through the following towns in Lake County. Buffalo Grove Riverswoods
Lincolnshire Vernon Hills Indian Creek
Mundelein
Libertyville
Grayslake
Gurnee
Lindenhurst Antioch U.S. Rt. 45 is multi-plexed in Lake County. Illinois State Route 21, from the Cook/Lake County Line to Lincolnshire.
U.S. Rt. 45 intersects the following highways in Lake County. Illinois State Route 22, at Lincolnshire.