U.S. Federal Route 45 runs through the extreme Southeastern Shelby County. It runs from the Cumberland/Shelby County Line, south of Neoga, to the Shelby/Effingham County Line, south of Sigel. U.S. Rt. 45 passes through the following town in Shelby County. Sigel U.S. Rt. 45 is not multi-plexed in Shelby County. U.S. Rt. 45 does not intersects any highways in Shelby County.
SB U.S. Rt. 45 at the Cumberland/Shelby County Line. SB U.S. Rt. 45 north of Sigel. SB U.S. R. 45 south of Sigel. A Shelby County mile marker. NB U.S. Rt. 45 at the Effingham/Shelby County Line.
