U.S. Federal Route 50 is a east-west highway in Central Clinton County. Many towns along the U.S. Rt. 50 corridor have been by-passed. U.S. Rt. 50 passes through the following town in Clinton County. Carlyle
WB U.S. Rt. 50 west of Trenton. WB U.S. Rt. 50 west of IL St Rt 160. A BGS on NB IL St Rt 160. WB U.S. Rt. 50 at IL St Rt 160. EB U.S. Rt. 50 near Trenton. WB U.S. Rt. 50 east of IL St Rt 160. WB U.S. Rt. 50 east of Trenton. WB U.S. Rt. 50 west of Aviston. WB U.S. Rt. 50 at Aviston. WB U.S. Rt. 50 west of St. Rose Road. WB U.S. Rt. 50 at St. Rose Road. WB U.S. Rt. 50 near St. Rose Road. WB U.S. Rt. 50 west of Breese. WB U.S. Rt. 50 at Breese. WB U.S. Rt. 50 at Breese. WB U.S. Rt. 50 east of Breese. WB U.S. Rt. 50 east of Breese. WB U.S. Rt. 50 near Shoal Creek. WB U.S. Rt. 50 at Frogtown Road. WB U.S. Rt. 50 near Frogtown Road. WB U.S. Rt. 50 near Beckemeyer. WB U.S. Rt. 50 near Beaver Creek. WB U.S. Rt. 50 near Flat Branch Road. WB U.S. Rt. 50 near Carlyle. WB U.S. Rt. 50 west of IL St Rt 127. EB U.S. Rt. 50/SB IL St Rt 127 in Carlyle. A junction marker on EB U.S. Rt. 50/SB IL St Rt 127. EB U.S. Rt. 50 east of Carlyle. EB U.S. Rt. 50 near Huey. EB U.S. Rt. 50 near Shattuc. EB U.S. Rt. 50 near the Clinton/Marion County Line. A Clinton County mile marker.