U.S. Federal Route 52 runs east-west across Central La Salle County. Much of this highway is in rural areas. U.S. Rt. 52 passes through the following towns in La Salle County. Serena
WB U.S. Rt. 52 at the Kendall/La Salle County Line. WB U.S. Rt. 52 in Eastern La Salle County. EB U.S. Rt. 52 east of IL St Rt 71. EB U.S. Rt. 52 east of IL St Rt 71. WB U.S. Rt. 52 near IL St Rt 71. WB U.S. Rt. 52 at IL St Rt 71. WB U.S. Rt. 52 west of IL St Rt 71. EB U.S. Rt. 52 near Sheridan. WB U.S. Rt. 52 near Sheridan. WB U.S. Rt. 52 east of the Fox River. WB U.S. Rt. 52 at the Fox River. EB U.S. Rt. 52 at the Fox River. EB U.S. Rt. 52 east of Serena. EB U.S. Rt. 52 at Serena. WB U.S. Rt. 52 at Hoxsey Road. WB U.S. Rt. 52 west of Serena. WB U.S. Rt. 52 east of Indian Creek. EB U.S. Rt. 52 eat of north IL St Rt 23. WB U.S. Rt. 52 at north IL St Rt 23. EB U.S. Rt. 52 east of IL St Rt 23. EB U.S. Rt. 52/IL St Rt 23 near Serena. A junction marker on EB U.S. Rt. 52/NB IL St Rt 23. SB IL St Rt 23/WB U.S. Rt. 52 at E 18th Road. A junction marker on NB IL St Rt 23. EB U.S. Rt. 52 at IL St Rt 23. WB U.S. Rt. 52 west of IL St Rt 23. EB U.S. Rt. 52 west of IL St Rt 23. EB U.S. Rt. 52 east of Prairie Center. EB U.S. Rt. 52 at Prairie Center. EB U.S. Rt. 52 west of Prairie Center. EB U.S. Rt. 52 near Prairie Center. EB U.S. Rt. 52 east of Triumph. EB U.S. Rt. 52 near Triumph. EB U.S. Rt. 52 east of I-39/U.S. Rt. 51. A BGS on NB I-39/U.S. Rt. 51. A BGS on SB I-39/U.S. Rt. 51. A BGS on NB I-39/U.S. Rt. 51. WB U.S. Rt. 52 west of I-39/U.S. Rt. 51. EB U.S. Rt. 52 west of I-39/U.S. Rt. 51. EB U.S. Rt. 52 west of I-39/U.S. Rt. 51. EB U.S. Rt. 52 east of Troy Grove. EB U.S. Rt. 52 east of Troy Grove. EB U.S. Rt. 52 east of Troy Grove. EB U.S. Rt. 52 at the Union Pacific railroad in Troy Grove. WB U.S. Rt. 52 in Troy Grove. EB U.S. Rt. 52 west of Troy Grove. EB U.S. Rt. 52 east of IL St Rt 251. EB U.S. Rt. 52 east of IL St Rt 251. EB U.S. Rt. 52 just east of IL St Rt 251. WB U.S. Rt. 52 east of south IL St Rt 251. A junction marker on EB U.S. Rt. 52/SB IL St Rt 251. WB U.S. Rt. 52/NB IL St Rt 251 north of south IL St Rt 251. EB U.S. Rt. 52/SB IL St Rt 251 near Troy Grove. WB U.S. Rt. 52/NB IL St Rt 251 south of Mendota. EB U.S. Rt. 52/SB IL St Rt 251. WB U.S. Rt. 52/NB IL St Rt 251 at the BNSF railroad in Mendota. WB U.S. Rt. 52/NB IL St Rt 251 in Mendota. WB U.S. Rt. 52/NB IL St Rt 251 at Washington Street in Mendota. A junction marker on WB U.S. Rt. 34. A street sign on WB U.S. Rt. 34. EB U.S. Rt. 52/SB IL St Rt 251 in Mendota. A junction marker on WB U.S. Rt. 52/NB IL St Rt 251. A La Salle County mile marker. WB U.S. Rt. 52 west of Mendota. WB U.S. Rt. 52 west of Mendota.
