U.S. Federal Route 52 runs east-west across Central La Salle County. Much of this highway is in rural areas. U.S. Rt. 52 passes through the following towns in La Salle County. Serena
WB U.S. Rt. 52 in Eastern La Salle County. WB U.S. Rt. 52 near IL St Rt 71. WB U.S. Rt. 52 near Sheridan. EB U.S. Rt. 52 at Serena. A junction marker on EB U.S. Rt. 52/NB IL St Rt 23. A junction marker on NB IL St Rt 23. EB U.S. Rt. 52 west of Prairie Center. A BGS on NB I-39/U.S. Rt. 51. WB U.S. Rt. 52 in Troy Grove. EB U.S. Rt. 52 west of Troy Grove. A junction marker on EB U.S. Rt. 52/SB IL St Rt 251. WB U.S. Rt. 52/NB IL St Rt 251 south of Mendota. WB U.S. Rt. 52/NB IL St Rt 251 at the BNSF railroad in Mendota. WB U.S. Rt. 52/NB IL St Rt 251 in Mendota. A junction marker on WB U.S. Rt. 52/NB IL St Rt 251. A La Salle County mile marker. WB U.S. Rt. 52 west of Mendota.