In La Salle County, U.S. Rt. 6 is a major east-west highway. This runs about one mile north of the Illinois River and Illinois & Michigan Canal, about one mile south of Interstate 80. U.S. Rt. 6 passes through the following towns. Peru
EB U.S. Rt. 6 in Peru. BGS on SB IL St Rt 251 in Peru. EB U.S. Rt. 6 in La Salle. BGS on NB I-39/U.S. Rt. 51. WB U.S. Rt. 6 west of IL St Rt 178. WB U.S. Rt. 6 near Utica. WB U.S. Rt. 6 on the westside of Ottawa. A junction marker on SB IL St Rt 23. EB U.S. Rt. 6/IL St Rt 71, east of Columbus Street (IL St Rt 23) in Ottawa. A junction marker on EB U.S. Rt. 6/IL St Rt 71 on the eastside of Ottawa. WB U.S. Rt. 6 between Marseilles and Ottawa. WB U.S. Rt. 6 in Marseilles. WB U.S. Rt. 6 near Seneca. Looking west on U.S. Rt. 6 at the La Salle/Grundy County Line east of Seneca.