Interstate 64, IndianaRoads of the Mid-South & West > Highways of the State of Indiana > Interstate 64, Indiana

Interstate 64

Interstate 64 is the southern most east-west interstate in the state of Indiana. It enters Indiana from Illinois on the west near Griffin. Then I-64 exits the state on the eastside in the Greater-Louisville (KY.) Metro Area. Portions of I-64 pass through the Hoosier National Forest Purchase Area.

On September 9th, 2011 at 5:00 p.m., in the middle of the afternoon rush hour, Indiana Governor Mitch Daniels ordered the Sherman Minton Bridge, which carries Interstate 64 over the Ohio River, and in and out of Indiana and Kentucky closed. This was due to a defect in a load bearing portion of the bridge. On Friday, February 17, 2012 conrete barriers were being removed an replaced with temporary barriers in prep for the bridges re-opening.

A VMS on EB I-64/U.S. Rt. 40 in St. Louis, MO. (September, 2011)


While in Indiana, Interstate 64 is multi-plexed.

I-64 is multi-plexed with...

...Indiana State Route 37, from M.P. 79 to M.P. 86.
...Indiana State Route 62, from M.P. 118 to M.P. 121.

...U.S. Rt. 150, from M.P. 119 to the Indiana/Kentucky State Line.


I-64 crosses the following interstates in Indiana.

Interstate 69, near Elberfeld.

EB I-64 two miles from I-69.

EB I-64 one mile from I-69.

EB I-64 at I-69.

Former Interstate 164, near Elberfeld. (Same interchange as I-69)

The two (2) mile BGS for I-164 on EB I-64.

EB I-64, one (1) mile from I-164.

EB I-64 at I-164.
Interstate 265, near New Albany/Clarksville.

The first BGS on EB I-64.

EB I-64 near I-265.

EB I-64 at I-265.

Branches of I-64 in Indiana.



EB I-64 at the Illinois/Indiana State Line.

EB I-64 near Giffin.

BGS on SB U.S. Rt. 41.

A guide sign on NB U.S. Rt. 41.

A BGS on NB U.S. Rt. 41.

A BGS on NB U.S. Rt. 41.

A guide marker on SB U.S. Rt. 41.

A BGS on SB U.S. Rt. 41.

A guide marker on SB U.S. Rt. 41.

A mile marker for the Traffic Wise program that IN D.O.T. operates.

EB I-64 east of U.S. Rt. 41.

EB I-64 at the Vanderburg/GIbson County Line.

EB I-64 west of I-69/IN St Rt 57.

EB I-64 at I-69/IN St Rt 57.

A BGS on NB I-69/IN St Rt 57.

Guide markers in Downtown Evansville.

WB I-64 in Western Floyd County.

A WB guide marker near Edwardsville. (Aug., 2004)

A odd pull through sign on WB I-64.

EB I-64/U.S. Rt. 150 in New Albany.

EB I-64/U.S. Rt. 150 near the Ohio River.

EB I-64/U.S. Rt. 150 at the Ohio River.

8 February 2019