Indiana State Route 16 runs east-west across Northern Cass County. It runs from the White/Cass County Line near Headlee, to the Cass/Miami County Line, near Perrysburg. IN St Rt 16 passes through the following towns in Cass County. Royal Center
Lucerne Metea Twelve Mile IN St Rt 16 is not multi-plexed in Cass County. IN St Rt 16 intersects the following highways in Cass County. U.S. Rt. 35, at Royal Center.