Indiana State Route 22 is an east-west highway in Central Howard County. It runs from the Carroll/Howard County Line, near Burlington, to the Howard/Grant County Line, near Sims. At Kokomo the highway stops at the city limits. All of the major highways that IN St Rt 22 crosses are on the eastern side of Kokomo. IN St Rt 22 passes through the following towns in Howard County. Kokomo Greentown IN St Rt 22 is multi-plexed in Howard County. U.S. Rt. 35, from Kokomo to the Howard/Grant County Line. Indiana State Route 19, from near Vermont to the Howard/Grant County Line. IN St Rt 22 intersects the following highways in Howard County. U.S. Rt. 31, at Kokomo. U.S. Rt. 35, at Kokomo. Indiana State Route 19, near Vermont. Indiana State Route 213, at Greentown.