Indiana State Route 66 runs east-west across Southern Spencer County. It runs from the Warrick/Spencer County Line, near Yankeetown, to the Spencer/Perry County Line, near Troy. IN St Rt 66 passes through the following towns in Spencer County. Hatfield Reo Rockport
IN St Rt 66 is multi-plexed in Spencer County. Indiana State Route 161, near Reo. IN St Rt 66 intersects the following highways in Spencer County. Indiana State Route 161, near Reo. Indiana State Route 161, at Reo. U.S. Rt. 231, near Rockport.