Iowa State Route 2 is a east-west highway across Fremont County. It runs from the Fremont/Page County Line, at Shenandoah, to the Iowa/Nebraska State Line, near Nebraska City, Nebraska. IA St Rt 2/Nebraska State Route 2 make up one of the few Missouri River crossings between Kansas City, MO/KS and Omaha, NE. IA St Rt 2 passes through the following towns in Fremont County. Shenandoah Sidney
IA St Rt 2 is multi-plexed in Fremont County. U.S. Rt. 275, from Sidney to near Riverton.
IA St Rt 2 intersects the following highways in Fremont County. U.S. Rt. 59, at Shenandoah.