Iowa State Route 81 is a short north-south highway in Southeastern Van Buren County. It runs from Iowa State Route 2, at Farmington, to Missouri State Route 81, at the Iowa/Missouri State Line. IA St Rt 81 passes through the following town in Van Buren County. Farmington.
IA St Rt 81 is not multi-plexed in Van Buren County. IA St Rt 81 intersects the following highway in Van Buren County. Iowa State Route 2, at Farmington.
A junction marker on WB IA St Rt 2. The northern end marker on IA St Rt 81. SB IA St Rt 81 south of Farmington. NB IA St Rt 81 at the Iowa/Missouri State Line.