U.S. Federal Route 52 runs north-south in Clayton County. It runs from the Dubuque/Clayton County Line in the southeastern part of the county, north of Luxemburg, to the Clayton/Allamakee County Line in the northwest corner of Clayton County, near Postville. U.S. Rt. 52 passes through the following towns in Clayton County. Millville
Guttenberg
Garnavillo Giard Monona Luana Postville U.S. Rt. 52 is multi-plexed in Clayton County. U.S. Rt. 18, from Girad to the Clayton/Allamakee County Line. U.S. Rt. 52 intersects the following highways in Clayton County. Iowa State Route 128, near Garnavillo. Iowa State Route 13, near Girad. U.S. Rt. 18, near Girad.
NB U.S. Rt. 52 at the Clayton/Dubuque County Line. NB U.S. Rt. 52 near 390th Rd. NB U.S. Rt. 52 near Millville. NB U.S. Rt. 52 north of Millville. NB U.S. Rt. 52 south of Guttenberg. NB U.S. Rt. 52 at Garber Road.
