U.S. Federal Route 61 is a north-south highway in Eastern Louis County. From the Muscatine/Louisa County Line, to just south of Grandview, the highway is a four-lane expressway. U.S. Rt. 61 passes through the following towns in Louisa County. Grandview Wapello
U.S. Rt. 61 is multi-plexed in Louisa County. Iowa State Route 92, from the Louisa/Muscatine County Line to Grandview.
U.S. Rt 61 intersects the following highways in Louisa County. Iowa State Route 92, at Grandview.
Iowa State Route 78, near Morning Star.
SB U.S. Rt. 61/WB IA St Rt 92 at the Louisa/Muscatine County Line. SB U.S. Rt. 61/WB IA St Rt 92 north of LCH 305. SB U.S. Rt. 61/WB IA St Rt 92 north of Grandview. A guide sign near Grandview. A guide sign near Grandview. A junction marker near Grandview. A guide sign on EB IA St Rt 92. SB U.S. Rt. 61 south of west IA St Rt 92. SB U.S. Rt. 61 south of Grandview. SB U.S. Rt. 61 south of Grandview. SB U.S. Rt. 61 south of Grandview. SB U.S. Rt. 61 south of 130th. SB U.S. Rt. 61 north of the Iowa River. SB U.S. Rt. 61 at the Iowa River. SB U.S. Rt. 61 south of the Iowa River. NB U.S. Rt. 61 north of Wapello. SB U.S. Rt. 61 south of Marshall Street in Wapello. SB U.S. Rt. 61 south of Franklin Street in Wapello.
