U.S. Federal Route 6 runs east-west across the extreme northern portion of Adair County. The entire length in the county is along Interstate 80. U.S. Rt. 6 does not pass through any towns in Adair County. U.S. Rt. 6 is multi-plexed in Adair County. Interstate 80, across the entire county.
U.S. Rt. 6 intersects the following highway in Adair County. Iowa State Route 25, near Casey.
EB I-80/U.S. Rt. 6 at the Cass/Adair County Line. EB I-80/U.S. Rt. 6 near Adair. EB I-80/U.S. Rt. 6 near Menlo.
