U.S. Federal Route 6 runs east-west across Cass County. It runs from the Pottawattamie/Cass County Line, near Lewis, to the Cass/Adair County Line, near Adair. U.S. Rt. 6 passes through the following town in Cass County. Atlantic U.S. Rt. 6 is multi-plexed in Cass County. Iowa State Route 83, near Atlantic. U.S. Rt. 71, near Atlantic. Interstate 80, from near Atlantic to the Cass/Adair County.
U.S. Rt. 6 intersects the following highways in Cass County. Iowa State Route 48, near Lewis. Iowa State Route 83, at Atlantic. U.S. Rt. 71, at Atlantic. Iowa State Route 83, near Atlantic. Interstate 80, near Atlantic. U.S. Rt. 71, near Atlantic. Iowa State Route 148, near Anita.
EB I-80/U.S. Rt. 6 near Anita. EB I-80/U.S. Rt. 6 at IA St Rt 148. EB I-80/U.S. Rt. 6 east of IA St Rt 148.
