U.S. Federal Route 159 runs briefly in North-Central Jefferson County. U.S. Rt. 159 passes through the following towns in Jefferson County. Nortonville U.S. Rt. 159 is not multi-plexed in Jefferson County. U.S. Rt. 159 intersects the following highways in Jefferson County. U.S. Rt. 59, at Nortonville. 4 August 2015 Shield at top of page from: Paul Dienhart