U.S. Federal Route 40 runs east-west across Wyandotte County. The entire length in the county is within Kansas City. U.S. Rt. 40 passes through the following town in Wyandotte County. Kansas City Bonner Springs
U.S. Rt. 40 is multi-plexed in Wyandotte County. U.S. Rt. 24, from the Leavenworth/Wyandotte County Line to Kansas City. U.S. Rt. 73, at Kansas City. Interstate 70, from Kansas City to the Kansas/Missouri State Line. U.S. Rt. 24, from Kansas City to the Kansas/Missouri State Line.