U.S. Federal Route 50 is a east-west highway in Lyons County. From Emporia to the Lyons/Coffey County Line, this highway runs along the Interstate 35 expressway. U.S. Rt. 50 passes through the following town in Lyons County. Emporia U.S. Rt. 50 is multi-plexed in Lyons County. Kansas State Route 57, from the Lyons/Chase County Line to Emporia. Interstate 35, from Emporia to the Coffey/Lyons County Line. U.S. Rt. 50 crosses the following highways in Lyons County. Interstate 35, at Emporia. (NO INTERCHANGE) Kansas Turnpike, at Emporia. (NO INTERCHANGE) Kansas State Route 57, at Emporia. Kansas State Route 99, at Emporia. Interstate 35, at Emporia. Kansas State Route 130, near Neosho Rapids.