Kentucky State Route 425 is a spur route running from the Pennyrile Parkway to U.S. Rt. 60, on the southside of Henderson. This is called the Henderson By-pass.
In 2016, KY St Rt 425 was truncated at U.S. Rt. 41. The section from U.S. Rt. 41 to the Pennyrile Parkway was renumbered U.S. Rt. 41. KY St Rt 425 passes through the following town in Henderson County. Henderson
KY St Rt 425 is multi-plexed in Henderson County. Kentucky State Route 136, at Henderson. KY St Rt 425 intersects the following highways in Henderson County. U.S. Rt. 41, at Henderson. Kentucky State Route 136, at Henderson. Kentucky Secondary State Route 1299, at Henderson. ALT. U.S. Rt. 41, at Henderson. U.S. Rt. 60, at Henderson. Kentucky State Route 136, at Henderson.