U.S. Federal Route 25E runs north-south in Central Bell County. It runs from the Cumberland Gap Tunnel, at the Kentucky/Tennessee State Line, at Middlesboro, to the Bell/Knox County Line, near Elys. U.S. Rt 25E passes through the following towns in Bell County. Middlesboro
SB U.S. Rt. 25E near and at the Cumberland Gap Tunnel. SB U.S. Rt. 25E near the Cumberland Gap Tunnel. SB U.S. Rt. 25E before the Cumberland Gap Tunnel. SB U.S. Rt. 25E at the Cumberland Gap Tunnel. SB U.S. Rt. 25E in the Cumberland Gap Tunnel. NB U.S. Rt. 25E at the Kentucky Welcome Sign. NB U.S. Rt. 25E at the Cumberland Gap National Park entrance. A guide sign for U.S. Rt. 25E at the Cumberland Gap National Park. NB U.S. Rt. 25E/TRUCK KY St Rt 74 south of Dansbury Avenue. NB U.S. Rt. 25E north of Middlesboro. NB U.S. Rt. 25E south of KY Sec St Rt 3486. NB U.S. Rt. 25E north of KY St Rt 188. NB U.S. Rt. 25E near Cannon Creek Lake. NB U.S. Rt. 25E south of KY Sec St Rt 1534. NB U.S. Rt. 25E north of KY Sec St Rt 1534. NB U.S. Rt. 25E near Woodland Hills. NB U.S. Rt. 25E south of KY St Rt 190. NB U.S. Rt. 25E at KY St Rt 190. NB U.S. Rt. 25E north of U.S. Rt. 119. NB U.S. Rt. 25E south of KY St Rt 66. NB U.S. Rt. 25E at KY St Rt 66. NB U.S. Rt. 25E at KY Sec St Rt 2015. NB U.S. Rt. 25E north of Pineville. NB U.S. Rt. 25E south of KY Sec St Rt 2014. NB U.S. Rt. 25E at KY Sec St Rt 2014. NB U.S. Rt. 25E near Fourmile.