U.S. Federal Route 45 is a north-south highway in Southeastern Fulton County. It is one of the main highways in the Fulton Area. This highway runs from the Hickman/Fulton County Line, northeast of Fulton, to the Kentucky/Tennessee State Line on the southwest side of Fulton. U.S. Rt. 45 passes through the following town in Fulton County. Fulton U.S. Rt. 45 is not multi-plexed in Fulton County. U.S. Rt. 45 intersects the following highways in Fulton County. Kentucky State Route 116, at Fulton.