Maryland State Route 781 is a north-south highway in Northeastern Cecil County. It runs from U.S. Rt. 40, at Elkton, to Maryland State Route 281, in Elkton. This highway is about a mile in length. MD St Rt 781 passes through the following town in Cecil County. Elkton
MD St Rt 781 is not multi-plexed in Cecil County. MD St Rt 316 crosses the following highways in Cecil County. U.S. Rt. 40, at Elkton. Maryland State Route 281, at ELkton.