Massachusetts State Route 10 is a north-south highway in Hampshire County. It runs from the Franklin/Hampshire County Line, near North Hatfield, to the Hampshire/Hampden County Line, near Russellville. MA St Rt 10 passes through the following towns in Hampshire County. Northampton Easthampton Southampton MA St Rt 10 is multi-plexed in Hampshire County. U.S. Rt. 5 from the Hampshire/Franklin County Line to Northampton. Massachusetts State Route 9, at Northampton. MA St Rt 10 intersects the following highways in Hampshire County. Massachusetts State Route 9, at Northampton. U.S. Rt. 5, at Northampton. Massachusetts State Route 9, at Northampton. Masachusetts State Route 141, at Easthampton.
