Massachusetts State Route 116 is a north-south highway in Hampden County. It runs from Springfield, north to the Hampden/Hampshire County Line, near Westover Air Reserve Base. MA St Rt 116 passes through the following towns in Hampden County. Springfield Chicopee Holyoke MA St Rt 116 is not multi-plexed in Hampden County. MA St Rt 116 crosses the following highways in Hampden County. Massachusetts State Route 20A, at Springfield. Interstate 91, at Springfield. Interstate 91, at Springfield. (NO Interchange) Interstate 391, at Springfield. Interstate 391, at Chicopee. Interstate 90 (Massachusetts Turnpike) at Chicopee. Interstate 391, at Chicopee. (NO Interchange) Massachusetts State Route 141, at Chicopee. (NO Interchange) Massachusetts State Route 141, at Holyoke. Massachusetts State Route 141, at Holyoke.
