Massachusetts State Route 150 is a short north-south highway in Northeastern Massachusetts. It runs from Beacon Street in Amesbury to the Massachusetts/New Hampshire State Line. MA St Rt 150 passes through the following town in Essex County. Amesbury MA St Rt 150 is not multi-plexed in Essex County. MA St Rt 150 intersects the following highways in Essex County. Interstate 495, near Amesbury. Massachusetts State Route 110, near Amesbury.