Massachusetts State Route 21 runs north-south in Northeastern Hampden County. It runs from U.S. Rt. 20/Massachusetts State Route 141, at Ludlow to the Hampden/Hampshire County Line, near Springfield Reservoir. MA St Rt 21 passes through the following towns in Hampden County. Ludlow Ludlow Center MA St Rt 21 is multi-plexed in Hampden County. Massachusetts State Route 141, at Ludlow. MA St Rt 21 intersects the following highways in Hampden County. U.S. Rt. 20, at Ludlow. Massachusetts State Route 141, at Ludlow. Massachusetts State Route 141, at Ludlow. Interstate 90, (Massachusetts Turnpike) at Ludlow.
