Massachusetts State Route 33 is a north south highway in North-Central Hampden County. It runs from MA St Rt 33 at Springfield, to the Hampden/Hampshire County Line. MA St Rt 33 passes through the following town in Hampden County. Springfield MA St Rt 33 is not multi-plexed in Hampden County. MA St Rt 33 intersects the following highways in Hampden County. Massachusetts State Route 141, at Springfield. Interstate 90, (Massachusetts Turnpike) at Springfield.