U.S. Federal Route 3 runs north-south in Northeastern Massachusetts. It only runs in Middlesex County while in the commonwealth. This runs from the New Hampshire/Massachusetts to Cambridge. U.S. Rt. 3 passes through the following towns in Middlesex County. Lowell Burlington
Woburn Arlington Cambridge U.S. Rt. 3 is multi-plexed in Middlesex County. Interstate 95, at Woburn.