Michigan State Route 216 runs east-west in Northwestern St. Joseph County. It goes from U.S. Rt. 131, near Moorepark, to the Cass/St. Joseph County Line. MI St Rt 216 passes through the following town in St. Joseph County. Howardville
MI St Rt 216 is not multi-plexed in St. Joseph County. MI St Rt 216 intersects the following highway in St. Joseph County. U.S. Rt. 131, near Moorepark.
A junction marker on SB U.S. Rt. 131.
WB MI St Rt 216 west of U.S. Rt. 131.
WB MI St Rt 216 at Howardsville.
EB MI St Rt 216 at the St. Joseph/Cass County Line.