Michigan State Route 216 runs east-west in Northwestern St. Joseph County. It goes from U.S. Rt. 131, near Moorepark, to the Cass/St. Joseph County Line. MI St Rt 216 passes through the following town in St. Joseph County. Howardville MI St Rt 216 is not multi-plexed in St. Joseph County. MI St Rt 216 intersects the following highway in St. Joseph County. U.S. Rt. 131, near Moorepark.
