Michigan State Route 60 is a east-west highway across Northern St. Joseph County. It runs from the Cass/St. Joseph County Line to Three Rivers. At Three Rivers it neads north to near Parkville. Near Parkville, MI St Rt 60 runs east to the Branch/St. Joseph County Line, near Leonidas. MI St Rt 60 passes through the following towns in St. Joseph County. Three Rivers
Mendon Leonidas MI St Rt 60 is multi-plexed in St. Joseph County. U.S. Rt. 131, at Three Rivers.