U.S. Federal Route 127 is a north-south highway in Eastern Hillsdale County. It enters from Jackson county in the northeastern portion of Hillsdale County, and runs and weaves along the Hillsdale/Lenawee County Line. The southern end of U.S. Rt. 127 in Hillsdale County is at the Michigan/Ohio State Line. U.S. Rt. 127 passes through the following town in Hillsdale County. Hudson
U.S. Rt. 127 is not multi-plexed in Hillsdale County. U.S. Rt. 127 intersects the following highway in Hillsdale County. Michigan State Route 34, at Hudson.
SB U.S. Rt. 127 at the Jackson/Hillsdale County Line. SB U.S. Rt. 127 at the Lenawee/Hillsdale County Line. SB U.S. Rt. 127 north of Hudson. SB U.S. Rt. 127 north of MI St Rt 34. SB U.S. Rt. 127 at MI St Rt 34. SB U.S. Rt. 127 south of Hudson. SB U.S. Rt. 127 north of the Ohio State Line. NB U.S. Rt. 127 at the Michigan Welcome Sign.