U.S. Federal Route 127 is a north-south highway in Eastern Isabella County. It runs from the Clare/Isabella County Line, at Clare, to the Isabella/Gratiot County Line, near Shepard. U.S. Rt. 127 passes through the followng towns in Isabella County. Clare
Branches of U.S. Rt. 127 in Isabella County. SB U.S. Rt. 127 at the Clare/Isabella County Line. SB U.S. Rt. 127 south of east U.S. Rt. 10. SB U.S. Rt. 127 north of Mt. Pleasant. SB U.S. Rt. 127 at BUSN U.S. Rt. 127 north of Mt. Pleasant. A guide marker on NB BUSN U.S. Rt. 127/EB MI St Rt 20. A guide marker on EB MI St Rt 20. A junction marker on EB MI St Rt 20. SB U.S. Rt. 127 south of MI St Rt 20. A BGS on NB U.S. Rt. 127. SB U.S. Rt. 127 south of Mt. Pleasent. SB U.S. Rt. 127 near Shepherd.