Mississippi State Route 6 runs east-west across Central Lafayette County. This is one of the main highways around Oxford. MS St Rt 6 passes through the following town in Lafayette County. Oxford
MS St Rt 6 is multi-plexed in Coahoma County. U.S. Rt. 278, through out Lafayette County.
EB U.S. Rt. 278/MS St Rt 6 east of the Lafayette/Panola County Line. EB U.S. Rt. 278/MS St Rt 6 south of Sardis Lake. EB U.S. Rt. 278/MS St Rt 6 west of Oxford. EB U.S. Rt. 278/MS St Rt 6 in Oxford. EB U.S. Rt. 278/MS St Rt 6 east of Oxford. EB U.S. Rt. 278/MS St Rt 6 near the Holly Springs National Forest. EB U.S. Rt. 278/MS St Rt 6 near Tula. EB U.S. Rt. 278/MS St Rt 6 west of the Lafayette Springs Area. EB U.S. Rt. 278/MS St Rt 6 near Lafayette Springs. EB U.S. Rt. 278/MS St Rt 6 near the Lafayette/Pontotoc County Line.
