U.S. Federal Route 61 is the main highway through Pike County. It runs along a four-lane highway in the central portion of the county. U.S. Rt. 61 passes through the following towns in Pike County. Eolia
Branches of U.S. Rt. 61 in Pike County. NB U.S. Rt. 61 south of MO Sec St Rt D/FF. NB U.S. Rt. 61 south of Edgewood. NB U.S. Rt. 61 at Bowling Green. A BGS on NB BUSN U.S. Rt. 61/SB MO St Rt 161. A junction marker on SB BUSN U.S. Rt. 61/NB MO St Rt 161. NB U.S. Rt. 61 north of Bowling Green. NB U.S. Rt. 61 south of Frankford. A BGS on WB MO Sec St Rt C. A junction marker on WB MO Sec St Rt B. A set of guide markers on WB MO Sec St Rt B. NB U.S. Rt. 61 south of the Pike/Ralls County Line.