U.S. Federal Route 67 is the main north-south highway in St. Francois County. This connects Farmington to the St. Louis Metro Area. U.S. Rt. 67 passes through the following towns in St. Francois County. Bonne Terre
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Farmington U.S. Rt. 67 is multi-plexed in St. Francois County. Missouri State Route 32, from near Park Hills to Farmington.
Missouri Secondary State Route W, at Farmington. Missouri Secondary State Route H, near Doe Run. Missouri Secondary State Route DD, near Knob Lick.
Branches of U.S. Rt. 67 in St. Francois County SB U.S. Rt. 67 at the Jefferson/St. Francois County Line. SB U.S. Rt. 67 south of MO Sec St Rt Y. SB U.S. Rt. 67 near Bonne Terre. SB U.S. Rt. 67/EB MO St Rt 32 in Farmington.