U.S. Federal Route 69 is a north-south highway in Eastern Clinton County. It runs from the Clay/Clinton County Line, near Lawson, to the Clinton/De Kalb County Line, at Cameron. U.S. Rt. 69 passes through the following town in Clinton County. Cameron U.S. Rt. 69 is multi-plexed in Clinton County. BUSN Loop I-35, at Cameron.
U.S. Rt. 69 intersects the following highways in Clinton County. Missouri Secondary State Route PP, near Lawson. Missouri Secondary State Route V, near Elmira. Missouri State Route 116, near Lathrop. Missouri Secondary State Route H, near Mirabile Missouri State Route 121, near Mirabile. Interstate 35, near Cameron. BUSN Loop I-35, at Cameron.