New York State Route 21 is a north-south highway in Central Ontario County. It runs from the Wayne/Ontario County Line, near Palmyra, to the Ontario/Steuben County Line, near North Cohocton. NY St Rt 21 passes through the following towns in Ontario County. Manchester Shortsville Chapin Canandaigua Cheshire Academy Bristol Springs Woodville Maples NY St Rt 21 is multi-plexed in Ontario County. New York State Route 332, near Canandaigua. U.S. Rt. 20, near Canadaigua. New York State Route 5, near Canadaigua. NY St Rt 21 intersects the following highwys in Ontario County. Interstate 90, (New York State Thruway) near Manchester. New York State Route 96, at Manchester. New York State Route 488, at Chapin. New York State Route 332, near Canandaigua. U.S. Rt. 20, at Canandaigua. New York State Route 5, at Canandaigua. U.S. Rt. 20, near Canandaigua. New York State Route 5, near Canandaigua. New York State Route 64, near Bristol Springs. New York State Route 245, near Naples. New York State Route 53, near Naples.
