New York State Route 378 is a short highway in Rensselaer County. This is located near Troy. It connects U.S. Rt. 4 to Interstate 787. NY St Rt 378 passes through the following town in Rensselaer County. Troy NY St Rt 378 is not multi-plexed in Rensselaer County. NY St Rt 378 intersects the following highways in Rensselaer County. U.S. Rt. 4, at Troy.