New York State Route 425 runs north-south in Northern Erie County. It runs from Interstate 290, to the Erie/Niagara County Line. NY St Rt 425 passes through the following town in Erie County. Tonawanda NY St Rt 425 is not multi-plexed in Erie County. NY St Rt 425 intersects the following highway in Erie County. Interstate 290, at Tonawanda.
