U.S. Federal Route 219 is a north-south highway in Central Erie County. It runs from the Cattaraugus/Erie County Line to West Seneca. From Interstate 90/New York State Thruway, at West Seneca, to New York State Route 39, near Springville, this is an expressway. It is known as the Southern Expressway. U.S. Rt. 219 passes through the following town in Erie County. West Seneca U.S. Rt. 219 is not multi-plexed in Erie County. U.S. Rt. 219 intersects the following highways in Erie County. Interstate 90, (New York State Thruway) at West Seneca. New York State Route 179, near West Seneca. U.S. Rt. 20A, near Orchard Park. New York State Route 391, near Hamburg. New York State Route 39, near Springville.