The Great Smokey Mountain Expressway runs east-west in Southwestern North Carolina. It runs from U.S. Rt. 19/74, near Bryson City, to Interstate 40/U.S. Rt. 74, near Clyde. This is a major truck route through Southwestern North Carolina. This is a multi-lane divided highway. It does vary between an expressway and freeway in different segments. The Great Smokey Mountain Expressway passes through the following cities.
Byrson City Sylva Waynesville Numbered Highways along the Great Smokey Mountain Expressway.